I did this illustration as a proposal for a client: it didn’t make it, but I like it. The main outlines are hand-drawn and inked with a 0.5 line pen. The color has completely been added in Illustrator, after converting the drawing to vector. Sure Illustrator color is not as smooth as done in Photoshop, but it’s really versatile.

To see the difference in usage, view an illustration of mine colored with Photoshop.